The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
Here we show that central administration of pyroglutamylated arginine-phenylamine-amide peptide (QRFP/26RFa) increases both food intake and locomotor activity, without any significant effect on energy expenditure, thermogenesis giantmouse jagt or reward.Germline knock out of either of the mouse QRFP receptor orthologs, Gpr103a and Gpr103b, did not